Autistic behavior in children with fragile X syndrome: prevalence, stability, and the impact of FMRP.
نویسندگان
چکیده
We examined autistic behavior in a cross-sectional sample of 179 children with fragile X syndrome (FXS) and a longitudinal subset of 116 children using the Childhood Autism Rating Scale (CARS) to (a) determine a prevalence of autistic behavior in FXS, (b) examine the stability of autistic ratings over time, and (c) assess the association between the fragile X mental retardation protein (FMRP) and autistic behavior. Approximately 21% of the sample of 129 children (25.9% of boys) scored at or above the cutoff for autism. CARS scores increased slowly, yet significantly, over time, and low levels of FMRP were associated with higher mean levels of autistic behavior as measured by the CARS.
منابع مشابه
The influence of environmental and genetic factors on behavior problems and autistic symptoms in boys and girls with fragile X syndrome.
OBJECTIVE Fragile X syndrome, caused by mutations in a single gene of the X chromosome (FMR1), is associated with neurobehavioral characteristics including social deficits with peers, social withdrawal, gaze aversion, inattention, hyperactivity, anxiety, depression, and autistic behavior. However, there is considerable variability in the behavioral and psychiatric problems among children with t...
متن کاملAutistic behavior, FMR1 protein, and developmental trajectories in young males with fragile X syndrome.
In the context of a longitudinal study, we assessed the relationship between ratings of autistic behavior, FMR1 protein expression (FMRP), and the developmental trajectories of 55 young males with fragile X syndrome. Autistic behavior, as measured by the Childhood Autism Rating Scale, was not related to FMRP expression. However, autistic behavior was a significant predictor of both developmenta...
متن کاملCompulsive, self-injurious, and autistic behavior in children and adolescents with fragile X syndrome.
Compulsive, self-injurious, and autistic behaviors were examined in 31 boys and 29 girls with fragile X syndrome aged 5 to 20 years. Self-injurious behavior occurred in 58% of boys and 17% of girls, whereas compulsive behavior occurred in 72% of boys and 55% of girls and did not appear to be associated with self-injurious behavior. Fifty percent of boys and 20% of girls met diagnostic criteria ...
متن کاملگزارش یک مورد سندرم ایکس شکننده همراه با ناهنجاری انگشتان
Fragile X Syndrome, the most common cause of inherited mental retardation, results from mutation in fragile X mental retardation gene (FMR1) on long arm of X chromosome, Xq27.3. Clinical features include moderate to severe mental retardation without neurologic deficit, long face, large ears, prominent jaw, macro-orchidism, attention deficit, behavior di...
متن کاملThe Role of Fragile X Mental
Introduction Fragile X Syndrome (FXS) is the most common form of inherited mental retardation, caused by a trinucleotide repeat expansion resulting in silencing of the fragile X mental retardation 1 (FMR1) gene in humans. The array of disorders caused by mutations in this single gene includes mental retardation and autistic behaviors. There is much evidence that the protein product, fragile X m...
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ورودعنوان ژورنال:
- American journal of medical genetics. Part A
دوره 140A 17 شماره
صفحات -
تاریخ انتشار 2006